Learn, Maintain and Improve Your Brain. We've got free puzzles and brain teasers too!
New on the Scene There are some new and controversial approaches to healing MCS, CFS, FMS, EHS and other similar conditions associated with toxicity, on the scene called brain retraining, neural retraining, limbic retraining or amygdala training that are proving to be helpful for many people in returning the mind and body to the parasympathetic state. Even though blood sugar is high, it is not available to the cell for energy. Which is perhaps why many cleaners are lemon-scented. Answering these questions can help your mood; and they can also help you live a longer, fuller life. Of course, every essential oil affects the human body in different ways, based on the dozens or hundreds of compounds in each oil. Kimberlyn, a year-old married mother living in Arizona is not your average patient.
Frankincense oil has long been revered in the Middle East, where it's been used in religious ceremonies as an anointing oil for thousands of years. It is also a popular ingredient in cosmetics, and has even been found in the remains of Anglo-Saxons and ancient Egyptians. I believe that frankincense oil is one of the top essential oils you can use for your health. It's known for its comforting properties, and is useful for visualizing, improving one's spiritual connection and helping overcome stress and despair.
Frankincense oil may also help in healthy cell regeneration and keep existing cells and tissues healthy. It's useful for skin health, and can help treat dry skin, reverse signs of aging and reduce the appearance of stretch marks and scars. The main components of frankincense oil are ketonic alcohol olibanol , resinous matters 30 to 60 percent and terpenes such as a-and p-pinene, camphene, dipentene and phellandrene.
The monoterpenes and sesquiterpenes are the most valuable elements of frankincense oil. According to the book, "Reference Guide for Essential Oils," by Connie and Alan Higley, monoterpenes help prevent and discharge toxins from your liver and kidneys, and have antiseptic, antibacterial, stimulating, analgesic weak and expectorant properties.
Meanwhile, sesquiterpenes can go beyond the blood-brain barrier and help simulate the limbic system of your brain, as well as your hypothalamus, and pineal and pituitary glands. The health benefits of frankincense oil are mostly attributed to its anti-inflammatory, astringent, antiseptic, disinfectant, digestive, diuretic and expectorant properties.
It also has cicatrisant, carminative, cytophylactic, emenagogue, uterine and vulnerary effects. Frankincense oil is considered a tonic, as it benefits all the systems operating in the body, including the digestive, respiratory, nervous and excretory systems. It also aids the absorption of nutrients and strengthens your immune system.
In addition, Indian frankincense or boswellin, also a member of the Boswellia genus, has been found to significantly reduce inflammation in animal studies. It is actually one of my personal favorites, as I have seen it work well as a natural painkiller for many of my former rheumatoid arthritis RA patients. It also regulates the menstrual cycle of premenopausal women.
Frankincense is also being studied for its potential to treat cancer. Scientists have observed that there's an agent in this oil that may help stop cancer from spreading. Frankincense oil is made by steam-distilling the raw resin.
When buying frankincense oil, make sure that you only choose percent pure essential oil of the highest quality. Also, do not confuse frankincense essential oil with fragrance oil. Essential oils come from plants, while fragrance oils are usually artificially created and often contain synthetic chemicals.
Although they smell good and are typically less expensive, fragrance oils do not give you the therapeutic benefits of organic essential oils. The effects and benefits of frankincense oil can be acquired by applying it topically, inhaling it using a diffuser or vaporizer or ingesting it in very small amounts. Meanwhile, using a diffuser or inhaler works for treating colds and clearing up respiratory blockages.
You can also sprinkle a few drops on a clean cloth and inhale the scent or add it to your bathwater for a rejuvenating soak. Frankincense oil can be directly applied to the skin or blended with other carrier oils such as jojoba or sweet almond oil. Yes, frankincense is generally safe. However, I advise doing a spot test first, to check if you have any sensitivity to this oil.
When taking frankincense oil internally, it's best to dilute a drop in an edible carrier oil like coconut oil , a teaspoon of honey or a glass of purified water or any non-acidic, non-dairy beverage.
Older children and teens may also require higher dilutions. There are no reported severe side effects of using this oil. In addition to immunomodulatory pathways, CB2-R receptors are involved in maintaining proper bone mass.
CB2-R agonists enhance endocortical osteoblast reproduction and activation, while inhibiting osteoclastogenesis. Endocannabinoids have a short life span. Other less important enzymatic pathways exist, demonstrating redundancy in EC degradation.
Interestingly, the catabolite AA is a precursor for the cyclooxygenase COX —2 enzyme, leading to a number of bioactive eicosanoids eg, prostaglandins, prostacyclin, thromboxane, leukotrienes. Their bioavailability is unknown. A buccal spray is approved for use for neuropathic pain associated with multiple sclerosis in Canada only. Unapproved use is employed in patients with upper motor neuron syndrome who have spasticity-related pain not controlled by conventional treatment.
CB1-R receptors activate the dopaminergic reward system. Commonly abused drugs, such as nicotine, opiates, THC, and alcohol, share a common pathway, the dopaminergic surge in the nucleus accumbens. Independent studies involving humans and mice, respectively, reported an increase in smoking cessation rates, decreased alcohol intake, and a reduction in cocaine-seeking behavior with CB1-R antagonism.
Rimonabant was sold in Europe for the treatment of obesity. It was not approved in the United States and later withdrawn because of psychiatric effects, especially depression. Nevertheless, the ECS is ubiquitous regulator of cellular function in both health and diseases, which offers many potential therapeutic targets. Below is a list of ECS agonist and antagonist intervention with therapeutic potential. Gut motility disorders, inflammatory bowel syndrome, chronic liver diseases, alcoholic liver disease.
In summary, the ECS is a unique and ubiquitous cell-signaling system that is just beginning to be understood. The biochemistry of EC synthesis, metabolism, and bioactivity has been difficult to study in the past. Newer techniques such as genetically modified animals, pharmacologic probes, and molecular biology promise to reveal some of these mysteries in the future.
The greater promise is that with this understanding, the ECS will yield an important therapeutic target for future pharmacologic therapy. State Medical Marijuana Laws. National Conference of State Legislatures. September 14, ; Accessed: Witkamp R, Meijerink J. Physical activity and the endocannabinoid system: Cell Mol Life Sci. Ramer R, Hinz B. Cannabinoids as Anticancer Drugs. J Altern Complement Med. Mechoulam R, Gaoni Y. The absolute configuration of deltatetrahydrocannabinol, the major active constituent of hashish.
Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J Pharmacol Exp Ther. A review on the monoacylglycerol lipase: Ohno-Shosaku T, Kano M. Endocannabinoid-mediated retrograde modulation of synaptic transmission. Katona I, Freund TF. Multiple functions of endocannabinoid signaling in the brain. Melis M, Pistis M. Mechoulam R, Parker LA. The endocannabinoid system and the brain. A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.
Stress regulates endocannabinoid-CB1 receptor signaling. Endocannabinoid signaling and food addiction. The endocannabinoid system controls food intake via olfactory processes.
Jamshidi N, Taylor DA. Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: Endocannabinoids in basal ganglia circuits: Endocannabinoid signalling and the deteriorating brain. Montecucco F, Di Marzo V. At the heart of the matter: Cannabinoids, endocannabinoids, and cancer. Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not "higher".
The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility. Peripheral cannabinoid receptor, CB2, regulates bone mass. Cannabinoid system and cyclooxygenases inhibitors. Alhouayek M, Muccioli GG. COXderived endocannabinoid metabolites as novel inflammatory mediators. A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use.
Subjective and physiological effects after controlled Sativex and oral THC administration. Endocannabinoids and neuropathic pain: Recent clinical experience with dronabinol. Unintentional weight loss in older adults. Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain: Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.
N Engl J Med. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: Risk of depressive episodes with rimonabant: Targeting the endocannabinoid system with cannabinoid receptor agonists: Chemical probes of endocannabinoid metabolism. Endocannabinoids as biomarkers of human reproduction. Received salary from Medscape for employment. Sign Up It's Free! If you log out, you will be required to enter your username and password the next time you visit.
Share Email Print Feedback Close. Overview Humans and animals alike naturally synthesize endocannabinoids, chemical compounds that activate the same receptors as deltatetrahydrocannabinol THC , the active component of marijuana Cannabis sativa. Cannabinoid binding receptor-1 predominantly in brain. Cannabinoid-binding receptor-2 predominantly in immune system.
Hydrophobic with limited mobility in an aqueous environment. Retrograde transmission in the brain; travels backward from postsynaptic to presynaptic cells. Formed from the internal lipid constituents of cellular membrane.